Ammonia → HCID 15692977, compound

HRID 1090023Notes

Reaction equation

HRID 1090023 reaction equation
[C:1]([NH:5][C:6]([C:8]1[O:12][N:11]=[C:10]([CH3:13])[C:9]=1[C:14]([O:16]C)=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH3:18]>O>[C:1]([NH:5][C:6]([C:8]1[O:12][N:11]=[C:10]([CH3:13])[C:9]=1[C:14]([NH2:18])=[O:16])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 15692973HCID 15692973, compound

Product 1

HCID 15692977HCID 15692977, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

4.0 g of methyl 5-tert-butylaminocarbonyl-3-methylisoxazole-4-carboxylate and 50 ml of concentrated ammonia are refluxed for 3 hours. After cooling, the mixture is diluted with water and extracted with dichloromethane and the organic phase is evaporated down. 5-tert-butylaminocarbonyl-3-methylisoxazole-4-carboxamide is obtained as colorless crystals of melting point 155°-158° C. (compound No. 1).

Workup

  1. temperatureAfter cooling
  2. extractionextracted with dichloromethane
  3. customthe organic phase is evaporated down

Sources & evidence

ORD record
ord-767ddc1d1e8a464db6fc6d89056d824d
Source dataset
uspto-grants-1992_01
Patent number
US05080708

Reaction notes

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