HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 15692977, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | HCID 15692973 | HCID 15692973 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 15692977 | HCID 15692977 | — |
Reaction Steps
4.0 g of methyl 5-tert-butylaminocarbonyl-3-methylisoxazole-4-carboxylate and 50 ml of concentrated ammonia are refluxed for 3 hours. After cooling, the mixture is diluted with water and extracted with dichloromethane and the organic phase is evaporated down. 5-tert-butylaminocarbonyl-3-methylisoxazole-4-carboxamide is obtained as colorless crystals of melting point 155°-158° C. (compound No. 1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05080708 |
| Source dataset | uspto-grants-1992_01 |
| ORD ID | ord-767ddc1d1e8a464db6fc6d89056d824d |
| Source note | uspto-grants-1992_01 |