Acetic Acid → HCID 19914288, compound

HRID 1090032Notes

Reaction equation

HRID 1090032 reaction equation
[NH2:1][C:2]1[C:7]2[C:8](=[O:18])[C:9]3[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=3[NH:11][C:12](=[O:13])[C:6]=2[CH:5]=[CH:4][CH:3]=1.[C:19](O)(=[O:21])[CH3:20].O>O1CCOCC1>[C:19]([NH:1][C:2]1[C:7]2[C:8](=[O:18])[C:9]3[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=3[NH:11][C:12](=[O:13])[C:6]=2[CH:5]=[CH:4][CH:3]=1)(=[O:21])[CH3:20]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 962WaterHCID 12517819HCID 12517819, compound

Product 1

HCID 19914288HCID 19914288, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To 2.5 g 10-amino-5,6-dihydro-11H-dibenzo(b,e)azepine-6,11-dione in 50 ml dioxane are added 2 ml anhydrous acetic acid. This mixture is kept at reflux for 2 hours then brought almost to dryness under reduced pressure, and then poured into water, filtered and dried. Yield 2 g (ethanol): melting point 270°-2° C.

Workup

  1. temperatureat reflux for 2 hours
  2. filtrationfiltered
  3. customdried

Sources & evidence

ORD record
ord-db376ed5bb294676b16b4b38595c2e99
Source dataset
uspto-grants-1992_01
Patent number
US05080905

Reaction notes

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