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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1090036Generated: November 2, 2026

Tris(hydroxymethyl)aminomethane → Mannitol

https://huagongshe.com/reaction/1090036

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTris(hydroxymethyl)aminomethaneHCID 6503—
Reactant(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanalHCID 107526—
ReactantHCID 131717141HCID 131717141—
ProductMannitolHCID 6251—

Reaction Steps

NAC and THAM were granulated separately with an aqueous solution of gum arabic and dextrose. The granulate was dried, mixed with flavour, saccharin and mannitol and pressed into tablets. A similar composition was prepared by replacing THAM with THAM carbonate (807 mg, corresponding to 534 mg of THAM).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05080906
Source datasetuspto-grants-1992_01
ORD IDord-f2b8810b369643d3a2c005557f8eb947
Source noteuspto-grants-1992_01