Tris(hydroxymethyl)aminomethane → Mannitol

HRID 1090036Notes

Reaction equation

HRID 1090036 reaction equation
C(O)C(N)(CO)CO.[O:9]=[CH:10][C@@H:11]([C@H:13]([C@@H:15]([C@@H:17]([CH2:19][OH:20])[OH:18])[OH:16])[OH:14])[OH:12].C(O)C(N)(CO)CO.C(=O)([O-])[O-]>>[CH2:19]([OH:20])[C@H:17]([C@H:15]([C@@H:13]([C@@H:11]([CH2:10][OH:9])[OH:12])[OH:14])[OH:16])[OH:18]

Participants

4

Reactant 3

HCID 6503Tris(hydroxymethyl)aminomethaneHCID 107526(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanalHCID 131717141HCID 131717141, compound

Product 1

HCID 6251Mannitol

Procedure

NAC and THAM were granulated separately with an aqueous solution of gum arabic and dextrose. The granulate was dried, mixed with flavour, saccharin and mannitol and pressed into tablets. A similar composition was prepared by replacing THAM with THAM carbonate (807 mg, corresponding to 534 mg of THAM).

Workup

  1. customThe granulate was dried
  2. additionmixed with flavour, saccharin and mannitol
  3. customA similar composition was prepared

Sources & evidence

ORD record
ord-f2b8810b369643d3a2c005557f8eb947
Source dataset
uspto-grants-1992_01
Patent number
US05080906

Reaction notes

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