Triphenylphosphine → [[1-(4-Fluorophenyl)-4-methyl-1,2,3-triazol-5-yl]-methyl]-triphenylphosphonium chloride

HRID 1090117Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH2:13][Cl:14])=[C:11]([CH3:15])[N:10]=[N:9]2)=[CH:4][CH:3]=1.[C:16]1([P:22]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C1(C)C=CC=CC=1>[Cl-:14].[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH2:13][P+:22]([C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)=[C:11]([CH3:15])[N:10]=[N:9]2)=[CH:4][CH:3]=1

Participants

Conditions

Temperature: 80 °C

Procedure

A solution of 1-(4-fluorophenyl)-4-methyl-5-chloromethyl-1,2,3-triazole (754 mg; 3.34 mmol), prepared as described in example 7, and triphenylphosphine (1.1 g; 4.18 mmol) in toluene (33 ml) was heated at 80° C. for 21 hours. Then, the reaction mixture was cooled to room temperature and kept at this temperature overnight. The precipitate was filtered by washing with a little amount of toluene and with ethyl ether. The title compound was obtained as a solid.

Workup

temperatureThen, the reaction mixture was cooled to room temperature
customkept at this temperature overnight
filtrationThe precipitate was filtered
washby washing with a little amount of toluene and with ethyl ether

Sources & evidence

ORD record: ord-b32cffe49eb842df8245ccd7fc504f71
Source dataset: uspto-grants-1992_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05081136

Reaction notes

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