Sodium hydride → HCID 53704830, compound

Participants

Reaction Steps

2-Acetyl-5-n-butoxy-4-methoxyaniline (320 mg), 60% sodium hydride (81 mg) and cyclopropylcarbonyl chloride (296 mg) were reacted in the same manner as in the preparation of compound 97 to obtain N-cyclopropylcarbonyl-2-acetyl-5-n-butoxy-4-methoxyaniline (360 mg). This compound (250 mg) and potassium t-butoxide (460 mg) were reacted with each other in the same manner as in the preparation of compound 95 to obtain 7-n-butoxy-2-cyclopropyl-6-methoxy-4(1H)-quinolone (compound 115, 90 mg).

Provenance & Evidence