Cyclopropanecarbonyl chloride → HCID 19914483, compound

Participants

Reaction Steps

2-Acetyl-4-ethoxy-5-methoxyaniline (490 mg), triethylamine (1.0 ml) and cyclopropylcarbonyl chloride (0.25 ml) were reacted in the same manner as in the preparation of compound 95 to give N-cyclopropylcarbonyl-2-acetyl-4-ethoxy-5-methoxyaniline (420 mg). This compound (380 mg) and potassium t-butoxide (770 mg) were reacted in the same manner as in the preparation of compound 95 to obtain 2-cyclopropyl-6-ethoxy-7-methoxy-4(1H)-quinolone (compound 119, 80 mg).

Provenance & Evidence