Hydrochloric Acid → HCID 53702257, compound
Reaction equation
[ClH:1].[CH3:2][C:3]([CH3:15])([CH3:14])[C:4](O)([CH2:7][N:8]1[CH:12]=[N:11][CH:10]=[N:9]1)[C:5]#[CH:6].[Br:16]N1C(=O)CCC1=O.[OH-:24].[Na+]>C(Cl)Cl>[Br:16][CH:6]=[C:5]([Cl:1])[C:4]([OH:24])([CH2:7][N:8]1[CH:12]=[N:11][CH:10]=[N:9]1)[C:3]([CH3:15])([CH3:14])[CH3:2]Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
Hydrogen chloride gas is passed into a solution of 1.93 g (10 mmol) of 4,4-dimethyl-3-hydroxy-3-[(1,2,4-triazol-1-yl)-methyl]-1-pentine in 30 ml of methylene chloride at -20° C. until saturation is reached. 1.8 g (20 mmol) of N-bromosuccinimide are then added in portions and the mixture is subsequently stirred at 0° C. for 1 hour and at room temperature for 12 hours. HCl and solvent are stripped off in vacuo and the residue is worked up with methylene chloride and dilute sodium hydroxide solution. 2.1 g (68% of theory) of 1-bromo-2-chloro-4,4-dimethyl-3-hydroxy-3-[(1,2,4-triazol-1-yl)-methyl]-1-pentene are thus obtained as a mixture of isomers of melting point 45°-48° C.
Sources & evidence
- ORD record
- ord-dd3abdca0bf240bebc06cd01f682d9b4
- Source dataset
- uspto-grants-1992_01
- Patent number
- US05081140
Reaction notes
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