反应详情

1.5 g (12 mmol) of the potassium salt of N-hydroxytriazole in 20 ml of absolute dimethylformamide were initially taken under nitrogen. A solution of 3.16 g (12 mmol) of 2-chloro-2,2-di-(4-fluorophenyl)-acetonitrile in dimethylformamide was added dropwise to this solution, a slightly exothermic reaction taking place. The mixture was stirred for a further 3 hours at room temperature. The reaction solution was evaporated down, the residue was added to water and the mixture was extracted with ethyl acetate. The product was obtained from ethyl acetate in the form of a pale yellow oil, which crystallized out on stirring with diisopropyl ether.

1. customa slightly exothermic reaction
2. customThe reaction solution was evaporated down
3. additionthe residue was added to water
4. extractionthe mixture was extracted with ethyl acetate
5. customThe product was obtained from ethyl acetate in the form of a pale yellow oil, which
6. customcrystallized out
7. stirringon stirring with diisopropyl ether