Methanol → HCID 13376629, compound

HRID 1090176Notes

Reaction equation

HRID 1090176 reaction equation
[H-].[H-].[H-].[H-].[Li+].[Al+3].[N:7]1([CH2:12][CH:13]([C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=2)[C:14](OC)=[O:15])[CH:11]=[N:10][CH:9]=[N:8]1.CO>C(OCC)C>[Cl:24][C:21]1[CH:22]=[CH:23][C:18]([CH:13]([CH2:12][N:7]2[CH:11]=[N:10][CH:9]=[N:8]2)[CH2:14][OH:15])=[CH:19][CH:20]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 19914727Methyl α-(4-chlorophenyl)-1H-1,2,4-triazole-1-propanoateHCID 21226445Aluminium lithium hydride

Product 1

HCID 13376629HCID 13376629, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

1.3 g of LiAlH4 is suspended in 170 ml of anhydrous diethyl ether under N2 atmosphere. Within one hour, 8 g of methyl α-(1H-1,2,4-triazol-1-ylmethyl)-4-chlorophenylacetate is introduced. The reaction is exothermic, and proceeds with solvent reflux. At the end of heat evolution, 10 ml of methanol in 50 ml of diethyl ether is added to destroy the excess of hydride.

Workup

  1. temperatureproceeds with solvent reflux
  2. customto destroy the excess of hydride

Sources & evidence

ORD record
ord-4bd18d60daf348ec8a77c05eef8b5ed5
Source dataset
uspto-grants-1992_01
Patent number
US05081141

Reaction notes

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