1-(p-Chlorobenzyl)-1-(4-fluorophenyl)hydrazine hydrochloride → 4-[1-(4-chlorobenzyl)-5-fluoro-3-methyl-1H-indol-2-yl]-2,2-dimethyl butanoic acid

HRID 1090208Notes

Reaction equation

HRID 1090208 reaction equation
Cl.[Cl:2][C:3]1[CH:18]=[CH:17][C:6]([CH2:7][N:8]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)N)=[CH:5][CH:4]=1.C[O:20][C:21](=[O:31])[C:22]([CH3:30])([CH3:29])[CH2:23][CH2:24][C:25](=O)[CH2:26][CH3:27]>C(O)(C)(C)C>[Cl:2][C:3]1[CH:18]=[CH:17][C:6]([CH2:7][N:8]2[C:10]3[C:15](=[CH:14][C:13]([F:16])=[CH:12][CH:11]=3)[C:26]([CH3:27])=[C:25]2[CH2:24][CH2:23][C:22]([CH3:30])([CH3:29])[C:21]([OH:31])=[O:20])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 145912421-(p-Chlorobenzyl)-1-(4-fluorophenyl)hydrazine hydrochlorideHCID 15678813Methyl-2,2-dimethyl-5-oxoheptanoate

Product 1

HCID 156788154-[1-(4-chlorobenzyl)-5-fluoro-3-methyl-1H-indol-2-yl]-2,2-dimethyl butanoic acid

Reagents, catalysts & solvents 1

HCID 6386tert-ButanolSolvent

Procedure

Following the method of Example 2, but using 1-[4-chlorobenzyl]-1-[4-fluorophenyl]hydrazine hydrochloride and methyl-2,2-dimethyl-5-oxoheptanoate as starting materials, in t-butanol as solvent, the title compound was prepared.

Sources & evidence

ORD record
ord-7360fb6f55e24820a802199fbb4ce4f1
Source dataset
uspto-grants-1992_01
Patent number
US05081145

Reaction notes

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