Hydrochloric Acid → HCID 178448847, compound

HRID 1090232Notes

Reaction equation

HRID 1090232 reaction equation
[Cl:1][C:2]1[C:3]2[C:4]3[C:8](=[C:9]([Cl:11])[CH:10]=1)[N:7]=[C:6]([NH:12][CH2:13][CH2:14][CH:15]([N:17]1[CH:21]=[CH:20][N:19]=[CH:18]1)[CH3:16])[C:5]=3[CH:22]=[CH:23][CH:24]=2.[ClH:25]>C(O)C>[ClH:1].[ClH:25].[Cl:1][C:2]1[C:3]2[C:4]3[C:8](=[C:9]([Cl:11])[CH:10]=1)[N:7]=[C:6]([NH:12][CH2:13][CH2:14][CH:15]([N:17]1[CH:21]=[CH:20][N:19]=[CH:18]1)[CH3:16])[C:5]=3[CH:22]=[CH:23][CH:24]=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178448846HCID 178448846, compound

Product 1

HCID 178448847HCID 178448847, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The product of Example 33 (0.53 gram) was dissolved in 150 ml of ethanol, and 1.5 ml of 2.3N ethanolic hydrogen chloride. The solution was concentrated to about 50 ml volume and diluted with 100 ml of diethyl ether. The precipitate of the title compound was collected, washed with diethyl ether, and dried; yield, 0.49 gram; mp 257° C.-259° C. with decomposition.

Workup

  1. concentrationThe solution was concentrated to about 50 ml volume
  2. additiondiluted with 100 ml of diethyl ether
  3. customThe precipitate of the title compound was collected
  4. washwashed with diethyl ether
  5. customdried
  6. customyield

Sources & evidence

ORD record
ord-6626b8360ce347a893dbd93f4d34b4d1
Source dataset
uspto-grants-1992_01
Patent number
US05081131

Reaction notes

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