HCID 61699856, compound → HCID 178422608, compound

HRID 1090244Notes

Reaction equation

HRID 1090244 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1C(C)CCN.[IH:12].[CH3:13][C:14]1[CH:15]=[CH:16][C:17]2[C:18]3[C:22]=1[N:21]=[C:20](SC)[C:19]=3[CH:25]=[CH:26][CH:27]=2>C(O)C>[IH:12].[CH3:13][C:14]1[CH:15]=[CH:16][C:17]2[C:18]3[C:22]=1[N:21]=[C:20]([NH:1][CH2:2][CH2:3][CH2:4][CH2:5][C:5]1[CH:6]=[N:1][CH:2]=[CH:3][CH:4]=1)[C:19]=3[CH:25]=[CH:26][CH:27]=2

Participants

4

Reactant 2

HCID 61699856HCID 61699856, compoundHCID 86745401HCID 86745401, compound

Product 1

HCID 178422608HCID 178422608, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
-10 °C

Procedure

To a solution of 2.6 grams of 4-(3-pryidinyl butylamine in 75 ml of ethanol, 5.1 grams of 8-methyl-2-methylthiobenz(cd)indole hydriodide was added. The mixture was then stirred and heated under reflux for 16 hours. The hot reaction mixture was clarified and the filtrate cooled at -10° C., yielding 4.75 grams of 8-methyl-N-(4-(3-pyridinyl)butyl)benz(cd)indol-2-amine hydriodide, m.p. 175°-176° C. with decomposition.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 16 hours

Sources & evidence

ORD record
ord-f3027b6d3900411592408b1817da994f
Source dataset
uspto-grants-1992_01
Patent number
US05081131

Reaction notes

Loading…