Hydrogen Bromide → HCID 15035104, compound

HRID 1090253Notes

Reaction equation

HRID 1090253 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8][N:9]([CH2:22][CH2:23][O:24]C)[C:10]2[C:18]3[CH:19]=[CH:20][CH:21]=[C:16]4[C:17]=3[C:12](=[CH:13][CH:14]=[CH:15]4)[N:11]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.Br>>[N:1]1([CH2:6][CH2:7][CH2:8][N:9]([CH2:22][CH2:23][OH:24])[C:10]2[C:18]3[CH:19]=[CH:20][CH:21]=[C:16]4[C:17]=3[C:12](=[CH:13][CH:14]=[CH:15]4)[N:11]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 15035103HCID 15035103, compound

Product 1

HCID 15035104HCID 15035104, compound

Procedure

Treatment of the compound of Example 127 with refluxing 48% HBr solution results in the demethylation of the compound. Removal of the HBr solution in vacuo and neutralization with alkali hydroxide solution yields the title compound.

Workup

  1. customresults in the demethylation of the compound
  2. customRemoval of the HBr solution in vacuo and neutralization with alkali hydroxide solution

Sources & evidence

ORD record
ord-389adb85157d452b82779632f234b02f
Source dataset
uspto-grants-1992_01
Patent number
US05081131

Reaction notes

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