反应详情

A solution of 12 g of N-(4-(1H-imidazol-1-yl)butyl)benz(cd)indol-2-amine in 300 ml of dichloromethane was treated with 100 ml of 2N ethanolic hydrogen chloride. The solution was then taken to dryness in vacuo. The gummy residue was dissolved in 100 ml of water, treated with activated carbon, clarified and the filtrate taken to dryness in vacuo. The residue was treated with 200 ml of ethanol and then taken to dryness in vacuo. The evaporation from ethanol was repeated twice. The final residue was dried at 40° C. over P2O5 in vacuo, giving 18.4 g of the desired product as a hygroscopic golden foamy solid.

1. additiontreated with activated carbon
2. customThe evaporation from ethanol
3. dry with materialThe final residue was dried at 40° C. over P2O5 in vacuo