Hydrochloric Acid → HCID 178478517, compound

HRID 1090260Notes

Reaction equation

HRID 1090260 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8][CH2:9][NH:10][C:11]2[C:19]3[CH:20]=[CH:21][CH:22]=[C:17]4[C:18]=3[C:13](=[CH:14][CH:15]=[CH:16]4)[N:12]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[ClH:23].C(O)C>ClCCl.O>[ClH:23].[ClH:23].[N:1]1([CH2:6][CH2:7][CH2:8][CH2:9][NH:10][C:11]2[C:19]3[CH:20]=[CH:21][CH:22]=[C:17]4[C:18]=3[C:13](=[CH:14][CH:15]=[CH:16]4)[N:12]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 178419796HCID 178419796, compound

Product 1

HCID 178478517HCID 178478517, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6344DichloromethaneSolvent

Procedure

A solution of 12 g of N-(4-(1H-imidazol-1-yl)butyl)benz(cd)indol-2-amine in 300 ml of dichloromethane was treated with 100 ml of 2N ethanolic hydrogen chloride. The solution was then taken to dryness in vacuo. The gummy residue was dissolved in 100 ml of water, treated with activated carbon, clarified and the filtrate taken to dryness in vacuo. The residue was treated with 200 ml of ethanol and then taken to dryness in vacuo. The evaporation from ethanol was repeated twice. The final residue was dried at 40° C. over P2O5 in vacuo, giving 18.4 g of the desired product as a hygroscopic golden foamy solid.

Workup

  1. additiontreated with activated carbon
  2. customThe evaporation from ethanol
  3. dry with materialThe final residue was dried at 40° C. over P2O5 in vacuo

Sources & evidence

ORD record
ord-60cfcd59d36a4273b05262bcab508c67
Source dataset
uspto-grants-1992_01
Patent number
US05081131

Reaction notes

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