HCID 19752416, compound → HCID 15035368, compound

HRID 1090270Notes

Reaction equation

HRID 1090270 reaction equation
[Cl:1][C:2]1[CH:27]=[CH:26][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([F:16])=[CH:13][CH:14]=3)[C:9]([S:17][CH3:18])=[C:8]2[CH:19]([CH3:25])[C:20]([O:22]CC)=[O:21])=[CH:4][CH:3]=1>O1CCCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([F:16])=[CH:13][CH:14]=3)[C:9]([S:17][CH3:18])=[C:8]2[CH:19]([CH3:25])[C:20]([OH:22])=[O:21])=[CH:26][CH:27]=1

Participants

3

Reactant 1

HCID 19752416HCID 19752416, compound

Product 1

HCID 15035368HCID 15035368, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following the procedure of Preparation 6, but using ethyl 1-(p-chlorobenzyl)-5-fluoro -α-methyl-3-methylthioindole-2-acetate from Step 1 as starting material and tetrahydrofuran as solvent, the title compound was prepared, mp 136°-140°.

Workup

  1. customthe procedure of Preparation 6

Sources & evidence

ORD record
ord-61061cbbddff42f8ba498c7725c0b4d6
Source dataset
uspto-grants-1992_01
Patent number
US05081138

Reaction notes

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