1-(p-Chlorobenzyl)-1-(4-fluorophenyl)hydrazine hydrochloride → 1-(p Chlorobenzyl)-5-fluoro-3-methylthioindole-2-propanoic acid

HRID 1090276Notes

Reaction equation

HRID 1090276 reaction equation
Cl.[Cl:2][C:3]1[CH:18]=[CH:17][C:6]([CH2:7][N:8]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)N)=[CH:5][CH:4]=1.[CH3:19][S:20][CH2:21][C:22](=O)[CH2:23][CH2:24][C:25]([O:27]C)=[O:26]>C(O)(C)(C)C>[Cl:2][C:3]1[CH:18]=[CH:17][C:6]([CH2:7][N:8]2[C:10]3[C:15](=[CH:14][C:13]([F:16])=[CH:12][CH:11]=3)[C:21]([S:20][CH3:19])=[C:22]2[CH2:23][CH2:24][C:25]([OH:27])=[O:26])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 145912421-(p-Chlorobenzyl)-1-(4-fluorophenyl)hydrazine hydrochlorideHCID 15035404Methyl 5-methylthio-4-oxopentanoate

Product 1

HCID 150353801-(p Chlorobenzyl)-5-fluoro-3-methylthioindole-2-propanoic acid

Reagents, catalysts & solvents 1

HCID 6386tert-ButanolSolvent

Procedure

Following the procedure of Example 10, but using 1-(p-chlorobenzyl)-1-(4-fluorophenyl)hydrazine hydrochloride and methyl 5-methylthio-4-oxopentanoate as starting materials and t-butanol as the solvent, the title compound was prepared.

Sources & evidence

ORD record
ord-813998cc6523476fb8a6c9ec92c8a37c
Source dataset
uspto-grants-1992_01
Patent number
US05081138

Reaction notes

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