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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1090276Generated: November 1, 2026

1-(p-Chlorobenzyl)-1-(4-fluorophenyl)hydrazine hydrochloride → 1-(p Chlorobenzyl)-5-fluoro-3-methylthioindole-2-propanoic acid

https://huagongshe.com/reaction/1090276

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(p-Chlorobenzyl)-1-(4-fluorophenyl)hydrazine hydrochlorideHCID 14591242—
ReactantMethyl 5-methylthio-4-oxopentanoateHCID 15035404—
Solventtert-ButanolHCID 6386—
Product1-(p Chlorobenzyl)-5-fluoro-3-methylthioindole-2-propanoic acidHCID 15035380—

Reaction Steps

Following the procedure of Example 10, but using 1-(p-chlorobenzyl)-1-(4-fluorophenyl)hydrazine hydrochloride and methyl 5-methylthio-4-oxopentanoate as starting materials and t-butanol as the solvent, the title compound was prepared.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05081138
Source datasetuspto-grants-1992_01
ORD IDord-813998cc6523476fb8a6c9ec92c8a37c
Source noteuspto-grants-1992_01