反应详情

To a solution of 200 mg of methyl 1-(p-chlorobenzyl) -3-(t-butylthio)-α,α-dimethyl -5-(i-propyl)-indole-2-propanoate (from Example 25) in 1.5 mL tetrahydrofuran (THF) was added 0.4 ml of a solution of lithium aluminum hydride (1.0M in THF) at 0° C. After 2 h at 0° C., the reaction mixture was quenched with saturated aqueous Na2SO4, diluted with ether and stirred at room temperature for 1 h. The resultant slurry was filtered and the filtrate concentrated to dryness. The resultant oil was purified by flash chromatography (eluant: hexane ethyl acetate, 8:2) to give the title compound as a viscous oil.

1. customthe reaction mixture was quenched with saturated aqueous Na2SO4
2. additiondiluted with ether
3. filtrationThe resultant slurry was filtered
4. concentrationthe filtrate concentrated to dryness
5. customThe resultant oil was purified by flash chromatography (eluant: hexane ethyl acetate, 8:2)