2-Amino-3-methylpyridine → 4-Imino-9-methyl-4H-pyrido[1,2-a]pyrimidine-3-carbonitrile

Participants

Reaction Steps

To 200 ml of ethanol were added 11.8 g (97 mmoles) of ethoxymethylenemalononitrile and 10.5 g (97 mmoles) of 2-amino-3-methylpyridine, and the reaction was carried out with stirring at room temperature for 2 hours. After completion of the reaction, the crystals precipitated were collected by filtration to obtain 13.5 g of 3-cyano-4-imino-9-methyl-4H-pyrido[1,2-a]pyrimidine. Yield: 76%.

Provenance & Evidence