HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1090329Generated: November 1, 2026
(-)-3-t-Butyldimethylsilyloxybutyric acid phenylthioester → (-)-3-Hydroxybutyric acid phenylthioester
https://huagongshe.com/reaction/1090329
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | (-)-3-t-Butyldimethylsilyloxybutyric acid phenylthioester | HCID 54408146 | — |
| Solvent | AcOH THF water | HCID 21877175 | — |
| Product | (-)-3-Hydroxybutyric acid phenylthioester | HCID 53886232 | 94% |
Reaction Steps
To 3.26 g (10.4 mmol) of (-)-3-t-butyldimethylsilyloxybutyric acid phenylthio ester was added 50 ml of acetic acid: THF:water (3:1:1) and the mixture was stirred at 50° C. for 24 hours. The resultant was concentrated and distilled (128° to 130° C./0.8 mmHg) to give 1.91 g of (-)-3-hydroxybutyric acid phenylthio ester (yield: 94%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05081238 |
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| Source dataset | uspto-grants-1992_01 |
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| ORD ID | ord-1ad6a6c7ae2049f7b6f8f5e35693f85f |
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| Source note | uspto-grants-1992_01 |
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