Methane → Tert-butyl 4-{2-[(3,5-bis-trifluoromethyl-benzyl)-(4-hydroxy-5'-isopropyl-2'-methoxy-biphenyl-2-ylmethyl)-amino]-pyrimidin-5-yloxy}-butyrate
Reaction equation
[C:63].[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][c:11]([CH2:26][N:27]([c:28]2[n:29][cH:30][c:31]([O:34][CH2:35][CH2:36][CH2:37][C:38](=[O:39])[O:40][C:41]([CH3:42])([CH3:43])[CH3:44])[cH:32][n:33]2)[CH2:45][c:46]2[cH:47][c:48]([C:56]([F:57])([F:58])[F:59])[cH:49][c:50]([C:52]([F:53])([F:54])[F:55])[cH:51]2)[c:12](-[c:15]2[c:16]([O:24][CH3:25])[cH:17][cH:18][c:19]([CH:21]([CH3:22])[CH3:23])[cH:20]2)[cH:13][cH:14]1.[CH3:60][CH2:61][OH:62].[Pd:64]>>[OH:8][c:9]1[cH:10][c:11]([CH2:26][N:27]([c:28]2[n:29][cH:30][c:31]([O:34][CH2:35][CH2:36][CH2:37][C:38](=[O:39])[O:40][C:41]([CH3:42])([CH3:43])[CH3:44])[cH:32][n:33]2)[CH2:45][c:46]2[cH:47][c:48]([C:56]([F:57])([F:58])[F:59])[cH:49][c:50]([C:52]([F:53])([F:54])[F:55])[cH:51]2)[c:12](-[c:15]2[c:16]([O:24][CH3:25])[cH:17][cH:18][c:19]([CH:21]([CH3:22])[CH3:23])[cH:20]2)[cH:13][cH:14]1Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-5280c470fad24be696870d908894be23
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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