Triphenylphosphine → HCID 19915295, compound

HRID 1090366Notes

Reaction equation

HRID 1090366 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[CH2:10][Cl:11])=[CH:4][C:3]=1[O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[C:19]1([P:25]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[Cl-:11].[F:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[CH2:10][P+:25]([C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)=[CH:4][C:3]=1[O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 11776TriphenylphosphineHCID 14404723HCID 14404723, compound

Product 1

HCID 19915295HCID 19915295, compound

Procedure

A mixture of E-3-(4-fluoro-3-phenoxyphenyl)-1-chloro-prop-2-ene (42 g), triphenylphosphine (42 g) an (300 cm3) was heated at the reflux temperature for 16 hours. After cooling, crystals of E-3-(4-fluoro-3-phenoxyphenyl)prop-2-er-1-yl triphenyl phosphonium chloride (68 g) were filtered from the reaction mixture, washed with dry diethyl ether, dried by suction and stored in a desiccator under vacuum.

Workup

  1. temperaturewas heated at the reflux temperature for 16 hours
  2. temperatureAfter cooling
  3. filtrationcrystals of E-3-(4-fluoro-3-phenoxyphenyl)prop-2-er-1-yl triphenyl phosphonium chloride (68 g) were filtered from the reaction mixture
  4. washwashed with dry diethyl ether
  5. customdried by suction
  6. customstored in a desiccator under vacuum

Sources & evidence

ORD record
ord-a77d2b21e904465e855cadaf951fb2c0
Source dataset
uspto-grants-1992_01
Patent number
US05081273

Reaction notes

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