HCID 67916300, compound → HCID 14770837, compound

HRID 1090374Notes

Reaction equation

HRID 1090374 reaction equation
Cl.[F:2][C:3]1[CH:11]=[C:10]([C:12]2[CH2:13][CH2:14][N:15]([CH3:18])[CH2:16][CH:17]=2)[C:9]([F:19])=[CH:8][C:4]=1[C:5]([OH:7])=[O:6]>O.[Pd]>[F:2][C:3]1[CH:11]=[C:10]([CH:12]2[CH2:13][CH2:14][N:15]([CH3:18])[CH2:16][CH2:17]2)[C:9]([F:19])=[CH:8][C:4]=1[C:5]([OH:7])=[O:6]

Participants

4

Reactant 1

HCID 67916300HCID 67916300, compound

Product 1

HCID 14770837HCID 14770837, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Procedure

2.53 g (10 mmoles) of 2,5-difluoro-4-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)benzoic acid hydrochloride in 100 ml water with 10% Pd/C catalyst was hydrogenated under pressure. Filtration and evaporation afforded the title compound.

Workup

  1. filtrationFiltration and evaporation

Sources & evidence

ORD record
ord-55ba80f2405e473eb2b3bd72d453dc3c
Source dataset
uspto-grants-1992_01
Patent number
US05081254

Reaction notes

Loading…