Cyclopropylamine → HCID 178471864, compound

HRID 1090377Notes

Reaction equation

HRID 1090377 reaction equation
C(O[CH:4]=[C:5]([C:11](=[O:27])[C:12]1[CH:17]=[C:16]([F:18])[C:15]([CH:19]2[CH2:24][CH2:23][N:22]([CH3:25])[CH2:21][CH2:20]2)=[CH:14][C:13]=1[F:26])[C:6]([O:8][CH2:9][CH3:10])=[O:7])C.[CH:28]1([NH2:31])[CH2:30][CH2:29]1>CCOCC>[CH:28]1([NH:31][CH:4]=[C:5]([C:11](=[O:27])[C:12]2[CH:17]=[C:16]([F:18])[C:15]([CH:19]3[CH2:20][CH2:21][N:22]([CH3:25])[CH2:23][CH2:24]3)=[CH:14][C:13]=2[F:26])[C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH2:30][CH2:29]1

Participants

4

Reactant 2

HCID 69828CyclopropylamineHCID 54318584HCID 54318584, compound

Product 1

HCID 178471864HCID 178471864, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of 3.81 g (10 mmoles) of ethyl α-(ethoxymethylene)-2,5-difluoro-4-(1-methyl-4-piperidinyl)-β-oxobenzenepropanoate in 50 ml of ether was treated with 0.60 g (10 mmoles) of cyclopropylamine. After standing overnight the mixture was evaporated to dryness to afford the title compound.

Workup

  1. customthe mixture was evaporated to dryness

Sources & evidence

ORD record
ord-f99075003c3447688ccbf7f87ba25ed6
Source dataset
uspto-grants-1992_01
Patent number
US05081254

Reaction notes

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