反应详情

A solution of 20.3 g (50 mmol) of 2-[3-(4-bromo-2,5-difluorophenyl)cyclopentyl]-1H-isoindole-1,3-(2H)-dione in 100 ml of concentrated hydrochloric acid and 100 ml of ethanol was heated at reflux for 4 hours. The ethanol was allowed to evaporate and the aqueous acid mixture was heated at reflux for 4 additional hours. The solution was filtered through a fiber glass pad to remove some insoluble material and the filtrate was evaporated in vacuo. The residue was triturated with ethanol which was also removed in vacuo to give 13.1 g of the title compound.

1. temperatureat reflux for 4 hours
2. customto evaporate
3. temperaturethe aqueous acid mixture was heated
4. temperatureat reflux for 4 additional hours
5. filtrationThe solution was filtered through a fiber glass pad
6. customto remove some insoluble material
7. customthe filtrate was evaporated in vacuo
8. customThe residue was triturated with ethanol which
9. customwas also removed in vacuo