Hydrochloric Acid → 2,5-Dichloropentylamine hydrochloride

Participants

Reaction Conditions

Reaction Steps

1,500 parts of hydrochloric acid (chemically pure) are added to 137.5 parts of tetrahydrofurfurylamine hydrochloride at room temperature. The reaction solution is then heated to 130° C. in a pressure apparatus. This raises the pressure up to 8 bar. After a reaction time of 24 hours, the mixture is cooled to a temperature of 25° C. The dark brown solution is treated with activated carbon and filtered until it is clear, and the mother liquor is concentrated in a rotary evaporator. Recrystallization from 1,200 parts of ethanol gives 130 parts of an analytically pure product, 2,5-dichloropentylamine hydrochloride, having the following formula ##STR35##

Provenance & Evidence