Hydrochloric Acid → HCID 19913678, compound

HRID 1090717Notes

Reaction equation

HRID 1090717 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[N:7][N:8]3[C:15](=[O:16])[C:14]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)=[CH:13][C:12]([C:23]([N:25]([CH3:27])[CH3:26])=[O:24])=[C:9]32)=[CH:4][CH:3]=1.Cl.C(O)C>CO>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][NH:7][N:8]3[C:15](=[O:16])[C:14]([C:17]4[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=4)=[CH:13][C:12]([C:23]([N:25]([CH3:27])[CH3:26])=[O:24])=[C:9]32)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 30666884H-Pyrido(2,1-a)phthalazine-1-carboxamide, 10-chloro-N,N-dimethyl-4-oxo-3-phenyl-

Product 1

HCID 19913678HCID 19913678, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

from 10-chloro-N,N-dimethyl-4-oxo-3-phenyl-4H-pyrido[2,1-a]phthalazine-1-carboxamide in methanol/glacial acetic acid (10:1), but without the addition of saturated methanolic hydrochloric acid, there is obtained 10-chloro-6,7-dihydro-N,N-dimethyl-4-oxo-3-phenyl-4H-pyrido[2,1-a]phthalazine-1-carboxamide of m.p. 250°-252° (ethanol);

Sources & evidence

ORD record
ord-aba33ed80220479085b39939e47b79ca
Source dataset
uspto-grants-1992_01
Patent number
US05082842

Reaction notes

Loading…