Hydrochloric Acid → HCID 19913719, compound

HRID 1090718Notes

Reaction equation

HRID 1090718 reaction equation
[O:1]=[C:2]1[N:7]2[N:8]=[CH:9][C:10]3[C:15]([C:6]2=[C:5]([C:16]([N:18]2[CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)=[O:17])[CH:4]=[C:3]1[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=[CH:14][CH:13]=[CH:12][CH:11]=3.Cl.C(#N)C>CO>[O:1]=[C:2]1[N:7]2[NH:8][CH2:9][C:10]3[C:15]([C:6]2=[C:5]([C:16]([N:18]2[CH2:19][CH2:20][O:21][CH2:22][CH2:23]2)=[O:17])[CH:4]=[C:3]1[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=[CH:14][CH:13]=[CH:12][CH:11]=3

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6342AcetonitrileHCID 19898598HCID 19898598, compound

Product 1

HCID 19913719HCID 19913719, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

from 4-[(4-oxo-3-phenyl-4H-pyrido[2,1-a]phthalazine-1-yl)carbonyl]morpholine in methanol/glacial acetic acid (10:1), but without the addition of saturated methanolic hydrochloric acid, there is obtained 4-[(6,7-dihydro-4-oxo-3-phenyl-4H-pyrido[2,1-a]phthalazin-1-yl)carbonyl]morpholine of m.p. 254°-257° (acetonitrile);

Sources & evidence

ORD record
ord-d66ee2a2778b46aeacedbd447d531376
Source dataset
uspto-grants-1992_01
Patent number
US05082842

Reaction notes

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