反应详情

To a 1:1 mixture of acetone and water (560 ml) was added 7-bromomethy1coumarin (7.0 g, 29.3 mmol). The resulting suspension was refluxed for 48 hrs at which time the reaction mixture became a clear solution. The solution was then cooled and neutralized with sodium bicarbonate (2.4 g, 29.3 mmol) and concentrated in vacuo to about 65 ml. A thick mass of crystals resulted. The crystals were collected by filtration to yield 5.27 g of product after drying in vacuo (100% of theory). The melting point was 116°-117° C.

1. temperatureThe resulting suspension was refluxed for 48 hrs at which time the reaction mixture
2. temperatureThe solution was then cooled
3. concentrationconcentrated in vacuo to about 65 ml
4. customA thick mass of crystals resulted
5. filtrationThe crystals were collected by filtration