HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Hydroxybenzyl alcohol → Benzenemethanol, 3-(2-quinolinylmethoxy)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Hydroxybenzyl alcohol | HCID 102 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-(Chloromethyl)quinoline hydrochloride | HCID 3083823 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Benzenemethanol, 3-(2-quinolinylmethoxy)- | HCID 14650410 | 103.2% |
Reaction Steps
20.0 g (93.5 mmoles) of 2-chloromethylquinoline hydrochloride, 11.6g (93.5 mmoles) of 3-hydroxybenzylalcohol and 7.48g (186.42 mmoles) of powdered sodium hydroxide are combined in 56 ml of dimethylsulfoxide. After stirring room temperature for 24 hours the mixture is poured into ice-water and the resulting solid is collected and dried to give 25.6g of 2-(3-hydroxymethylphenoxy)methylquinoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05082849 |
| Source dataset | uspto-grants-1992_01 |
| ORD ID | ord-a6e014de1fa54ef1b0de1cb0c3a9027d |
| Source note | uspto-grants-1992_01 |