HRID1090784

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID4875

Potassium iodide

HCID14774163

未命名化合物

HCID19913868

未命名化合物

PRODUCTS

生成物

结构：CCCOC(=O)c1cc(=O)c2c(OCc3ccc(OCc4ccc5ccccc5n4)cc3)c(Cl)ccc2o1

HCID19913858

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID180

Acetone

C3H6O

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

0.78 g of 2-(4-chloromethylphenoxy)methylquinoline, 0.76 g of 2-carbopropoxy-6-chloro-5-hydroxy-4-oxo-4H-1-benzopyran and a catalytic amount of potassium iodide are combined in 50 ml of acetone and 2 ml of dimethylformamide, and refluxed for 19 hours. The crude solid obtained on cooling is purified by flash chromatography to give 2-carbopropoxy-6-chloro-5-(4-(quinolin-2-ylmethoxy)benzyloxy) 4-oxo-4H-1-benzopyran having an m.p. of 173°-74° C.

WORKUP

后处理

customThe crude solid obtained
temperatureon cooling
customis purified by flash chromatography

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-45ebf63c475c4eb680b5b89e419100eb
来源数据集: uspto-grants-1992_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05082849
来源说明: uspto-grants-1992_01

反应 SMILES

Cl[CH2:2][C:3]1[CH:20]=[CH:19][C:6]([O:7][CH2:8][C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:10]=2)=[CH:5][CH:4]=1.[C:21]([C:27]1[O:28][C:29]2[CH:37]=[CH:36][C:35]([Cl:38])=[C:34]([OH:39])[C:30]=2[C:31](=[O:33])[CH:32]=1)([O:23][CH2:24][CH2:25][CH3:26])=[O:22].[I-].[K+]>CC(C)=O.CN(C)C=O>[C:21]([C:27]1[O:28][C:29]2[CH:37]=[CH:36][C:35]([Cl:38])=[C:34]([O:39][CH2:2][C:3]3[CH:20]=[CH:19][C:6]([O:7][CH2:8][C:9]4[CH:18]=[CH:17][C:16]5[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=5)[N:10]=4)=[CH:5][CH:4]=3)[C:30]=2[C:31](=[O:33])[CH:32]=1)([O:23][CH2:24][CH2:25][CH3:26])=[O:22]