HRID1090796

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID702

Ethanol

C2H6O

HCID516892

Sodium Bicarbonate

CHNaO3

结构：CCOC(=O)c1oc2cc(OCc3ccc(OCc4ccc5ccccc5n4)cc3)cc(O)c2c(=O)c1-c1ccc(OC)cc1

HCID19913832

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(-c2c(C(=O)O)oc3cc(OCc4ccc(OCc5ccc6ccccc6n5)cc4)cc(O)c3c2=O)cc1

HCID19913861

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

0.14 g 2-carboethoxy-5-hydroxy-3-(4-methoxyphenyl)-7-(4-(quinolin-2-ylmethoxy)benzyloxy)-4-oxo-4H-1-benzopyran and 0.78 g sodium bicarbonate are combined in 7 ml of water and 7 ml of ethanol and refluxed overnight. The mixture is extracted with ether and the aqueous neutralized to pH6. The resulting solid is collected, dried to give 2-carboxy-5-hydroxy-3-(4-methoxyphenyl)-7-(4-(quinolin-2-ylmethoxy)benzyloxy)-4-oxo-4H-1H-benzopyran; m.p. 195°-96° C.

WORKUP

后处理

extractionThe mixture is extracted with ether
customThe resulting solid is collected
customdried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d89461cf373947fa8db39e8cb424cfc2
来源数据集: uspto-grants-1992_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05082849
来源说明: uspto-grants-1992_01

反应 SMILES

[C:1]([C:6]1[O:7][C:8]2[CH:24]=[C:23]([O:25][CH2:26][C:27]3[CH:32]=[CH:31][C:30]([O:33][CH2:34][C:35]4[CH:44]=[CH:43][C:42]5[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=5)[N:36]=4)=[CH:29][CH:28]=3)[CH:22]=[C:21]([OH:45])[C:9]=2[C:10](=[O:20])[C:11]=1[C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1)([O:3]CC)=[O:2].C(=O)(O)[O-].[Na+].C(O)C>O>[C:1]([C:6]1[O:7][C:8]2[CH:24]=[C:23]([O:25][CH2:26][C:27]3[CH:32]=[CH:31][C:30]([O:33][CH2:34][C:35]4[CH:44]=[CH:43][C:42]5[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=5)[N:36]=4)=[CH:29][CH:28]=3)[CH:22]=[C:21]([OH:45])[C:9]=2[C:10](=[O:20])[C:11]=1[C:12]1[CH:13]=[CH:14][C:15]([O:18][CH3:19])=[CH:16][CH:17]=1)([OH:3])=[O:2]