反应详情

温度

70 °C

A mixture of 2-benzoylpyrrole (855 mg, 5 mmol), diethyl malonate (800 mg, 5 mmol), manganese(III) acetate dihydrate (4560 mg, 15 mmol) and sodium acetate (820 mg, 10 mmol) in acetic acid (30 mL) was stirred at 70° C. under a nitrogen atmosphere. The reaction mixture was diluted with diethyl ether and filtered. The filtrate was washed with 10% aqueous sodium hydroxide and saturated aqueous sodium chloride, dried (Na2SO4), and concentrated under reduced pressure. The residue was purified by column chromatography on silica eluting with hexane/ethyl acetate (70:30) to provide 1.00 g (57%) of diethyl (5-benzoylpyrrol-2-yl)acetoxy-methanedicarboxylate.

1. filtrationfiltered
2. washThe filtrate was washed with 10% aqueous sodium hydroxide and saturated aqueous sodium chloride
3. dry with materialdried (Na2SO4)
4. concentrationconcentrated under reduced pressure
5. customThe residue was purified by column chromatography on silica eluting with hexane/ethyl acetate (70:30)