Benzaldehyde → HCID 67909180, compound

HRID 1090838Notes

Reaction equation

HRID 1090838 reaction equation
[ClH:1].Cl.[CH3:3][O:4][C:5]1[CH:6]=[C:7]([CH2:13][CH2:14][NH:15][CH2:16][CH:17]([OH:28])[CH2:18][O:19][C:20]2[N:21]=[N:22][C:23]([NH:26][NH2:27])=[CH:24][CH:25]=2)[CH:8]=[CH:9][C:10]=1[O:11][CH3:12].[CH:29](=O)[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>CO>[ClH:1].[ClH:1].[CH3:3][O:4][C:5]1[CH:6]=[C:7]([CH2:13][CH2:14][NH:15][CH2:16][CH:17]([OH:28])[CH2:18][O:19][C:20]2[N:21]=[N:22][C:23]([NH:26][N:27]=[CH:29][C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)=[CH:24][CH:25]=2)[CH:8]=[CH:9][C:10]=1[O:11][CH3:12]

Participants

4

Reactant 2

HCID 240BenzaldehydeHCID 19913985HCID 19913985, compound

Product 1

HCID 67909180HCID 67909180, compoundYield 8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of (RS)-3-[3-[[2-(3,4-Dimethoxyphenyl)ethyl)amino]-2-hydroxypropoxy]-6-hydrazinopyridazine dihydrochloride (2 g) in 40 ml of 90% aqueous methanol, (1 ml) of benzaldehyde was added. Stirring was continued at room temperature for two hours, then the solvent was evaporated under vacuum and the residue was triturated with isopropanol to afford the title compound in 8% yield. m.p. 207°-210° C. (with decomp).

Workup

  1. customthe solvent was evaporated under vacuum
  2. customthe residue was triturated with isopropanol

Sources & evidence

ORD record
ord-71d23fc5fa764f12adf2156fa94bd949
Source dataset
uspto-grants-1992_01
Patent number
US05082939

Reaction notes

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