反应详情

A mixture of 3-(1-chlorotridecyl)-5-trimethylsilylfuran (468 mg, 1.31 mmol) and sodium azide (852 mg, 13.1 mmol) in dry dimethylformamide (2 ml) was stirred at 60 degrees for 6 days. Most of the solvent was evaporated under high vacuum and the residue dissolved in water. Extraction (ethyl ether) and evaporation of the dried (magnesium sulfate) extracts gave an oil, which was flash chromatographed on silica using 5% ethyl ether/hexane. Fractions with Rf of about 0.73 on evaporation gave the title azide as a very pale yellow oil.

1. customMost of the solvent was evaporated under high vacuum
2. dissolutionthe residue dissolved in water
3. extractionExtraction (ethyl ether) and evaporation of the
4. dry with materialdried (magnesium sulfate)
5. customextracts gave an oil, which
6. customchromatographed on silica using 5% ethyl ether/hexane
7. customFractions with Rf of about 0.73 on evaporation