Potassium Carbonate → HCID 19912202, compound

HRID 1090995Notes

Reaction equation

HRID 1090995 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([O:9][C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][C:11]=2[Cl:17])=[CH:4][C:3]=1[N:18]1[C:22](=[O:23])[N:21]([CH:24]([F:26])[F:25])[C:20]([CH3:27])=[N:19]1.Br[CH:29]([CH3:34])[C:30]([O:32][CH3:33])=[O:31].C(=O)([O-])[O-].[K+].[K+]>C(C(C)=O)C>[Cl:8][C:6]1[CH:7]=[C:2]([Cl:1])[C:3]([N:18]2[C:22](=[O:23])[N:21]([CH:24]([F:26])[F:25])[C:20]([CH3:27])=[N:19]2)=[CH:4][C:5]=1[O:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][CH:29]([CH3:34])[C:30]([O:32][CH3:33])=[O:31])=[CH:12][C:11]=1[Cl:17]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 95576Methyl 2-bromopropionateHCID 19912206HCID 19912206, compound

Product 1

HCID 19912202HCID 19912202, compoundYield 51.5%

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

In a manner similar to Step D of Example 1, the reaction of 1.3 g (0.0029 mole) of 1-[2,4-dichloro-5-(2-chloro-4-hydroxyphenoxy)phenyl]-4-difluoromethyl-4,5-dihydro-3-methyl-1,2,4-triazol-5(1H)-one with 0.73 g (0.0044 mole) of methyl 2-bromopropionate and 0.60 g (0.0044 mole) of potassium carbonate in 60 ml of methyl ethyl ketone yielded 0.78 g of methyl 2-[4-[2,4-dichloro-5-(4-difluoromethyl-4,5-dihydro -3-methyl-5-oxo-1H-1,2,4-triazol-1-yl)phenoxy]-3-chlorophenoxy]propionate as an oil, compound 150 of Table 1.

Sources & evidence

ORD record
ord-6a5e2c3c6e124a3a91bddc4c24aea3fc
Source dataset
uspto-grants-1992_01
Patent number
US05084085

Reaction notes

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