Nitric Acid → 6-Methyl-2-nitropyridin-3-ol

HRID 1091011Notes

Reaction equation

HRID 1091011 reaction equation
[OH:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:8])=[N:6][CH:7]=1.[N+:9]([O-])([OH:11])=[O:10]>S(=O)(=O)(O)O>[N+:9]([C:7]1[C:2]([OH:1])=[CH:3][CH:4]=[C:5]([CH3:8])[N:6]=1)([O-:11])=[O:10]

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 142752-Methyl-5-hydroxypyridine

Product 1

HCID 848016-Methyl-2-nitropyridin-3-ol

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

5.45 g (50 mmol) of 5-hydroxy-2-methylpyridine are added to 20 ml of concentrated sulfuric acid, cooling in an ice bath. The temperature is maintained at 30 6° C. and 2.35 ml of fuming nitric acid are added with stirring. The mixture is left overnight at room temperature. 100 g of ice are added with stirring. The product is filtered off, rinsed with water and dried.

Workup

  1. temperaturecooling in an ice bath
  2. additionare added
  3. stirringwith stirring
  4. filtrationThe product is filtered off
  5. washrinsed with water
  6. customdried

Sources & evidence

ORD record
ord-ff1ef414d7ad48feb57740a8a187c5f6
Source dataset
uspto-grants-1992_01
Patent number
US05084456

Reaction notes

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