Nitric Acid → 6-Methyl-2-nitropyridin-3-ol

Participants

Reaction Steps

5.45 g (50 mmol) of 5-hydroxy-2-methylpyridine are added to 20 ml of concentrated sulfuric acid, cooling in an ice bath. The temperature is maintained at 30 6° C. and 2.35 ml of fuming nitric acid are added with stirring. The mixture is left overnight at room temperature. 100 g of ice are added with stirring. The product is filtered off, rinsed with water and dried.

Provenance & Evidence