Bromine → 6-Bromo-3H-oxazolo(4,5-b)pyridin-2-one

HRID 1091014Notes

Reaction equation

HRID 1091014 reaction equation
[O:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[NH:3][C:2]1=[O:10].[Br:11]Br>CN(C)C=O>[Br:11][C:7]1[CH:8]=[C:9]2[O:1][C:2](=[O:10])[NH:3][C:4]2=[N:5][CH:6]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 2799900Oxazolo(4,5-b)pyridin-2(3H)-one

Product 1

HCID 136144586-Bromo-3H-oxazolo(4,5-b)pyridin-2-one

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.01 mol of oxazolo[4,5-b]pyridin-2-one is dissolved in 100 ml of dimethylformamide. 0.011 mol of bromine is added via a dropping funnel. Stirring is maintained for 1 hour 30 minutes at room temperature and an ice/water mixture is added. The product is filtered off. It is washed with water. The product is dried.

Workup

  1. filtrationThe product is filtered off
  2. washIt is washed with water
  3. customThe product is dried

Sources & evidence

ORD record
ord-053ed7f23c804583b708391e4db701a4
Source dataset
uspto-grants-1992_01
Patent number
US05084456

Reaction notes

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