Ammonia → HCID 178522600, compound

HRID 1091025Notes

Reaction equation

HRID 1091025 reaction equation
[NH2:1][C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11](=S)[NH:12][C:13](=[O:21])[C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=1)=[O:3].N.OO>CO>[Cl:20][C:17]1[CH:18]=[CH:19][C:14]([C:13]([NH:12][C:11]2[NH:10][C:5]3[C:4]([C:2](=[O:3])[N:1]=2)=[CH:9][CH:8]=[CH:7][CH:6]=3)=[O:21])=[CH:15][CH:16]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 784Hydrogen PeroxideHCID 6676412-[(4-Chlorobenzoyl)carbamothioylamino]benzamide

Product 1

HCID 178522600HCID 178522600, compoundYield 47.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a stirred mixture of 10 g of the above benzamide, 100 ml of methanolic ammonia and 100 ml of methanol was added dropwise 25 ml of 30% hydrogen peroxide, during 10 minutes. The mixture was stirred overnight, the solid was collected, and then partially dissolved in 500 ml of hot acetonitrile. The undissolved solid was collected, mixed with 100 ml of hot water and the solid collected, giving 4.3 g of the desired product as off-white crystals, mp 239°-241° C. (dec.).

Workup

  1. customthe solid was collected
  2. dissolutionpartially dissolved in 500 ml of hot acetonitrile
  3. customThe undissolved solid was collected
  4. additionmixed with 100 ml of hot water
  5. customthe solid collected

Sources & evidence

ORD record
ord-102e4406ee21455392845f19147a6ed2
Source dataset
uspto-grants-1992_01
Patent number
US05084457

Reaction notes

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