反应详情

To a stirred mixture of 9.3 g of the above benzamide and 200 ml of methanolic ammonia was added dropwise, 10 ml of 30% hydrogen peroxide over 3 minutes. An exotherm required cooling in an ice bath. A 15 ml portion of 30% hydrogen peroxide was added, the mixture was stirred 48 hours, the solid collected, and mixed with 100 ml of hot water. This solid was collected, mixed with 400 ml of hot acetonitrile and filtered. The filtrate was chilled, giving 2.3 g of the desired product as off-white crystals, mp 211°-213° C.

1. additionwas added dropwise
2. temperatureAn exotherm required cooling in an ice bath
3. customthe solid collected
4. additionmixed with 100 ml of hot water
5. customThis solid was collected
6. additionmixed with 400 ml of hot acetonitrile
7. filtrationfiltered
8. temperatureThe filtrate was chilled