Acetonitrile → HCID 19913021, compound

HRID 1091065Notes

Reaction equation

HRID 1091065 reaction equation
[CH3:1][N:2]1[CH2:7][C:6]([N+:8]([O-:10])=[O:9])=[C:5](SC)C(C)[CH:3]1CN.[N:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[CH2:22][NH2:23].[C:24](#[N:26])C>>[CH3:24][N:26]1[CH2:5][C:6]([N+:8]([O-:10])=[O:9])=[C:7]([NH:23][CH2:22][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][N:16]=2)[N:2]([CH3:1])[CH2:3]1

Participants

4

Reactant 3

HCID 6342AcetonitrileHCID 195092-PyridinemethanamineHCID 19913006HCID 19913006, compound

Product 1

HCID 19913021HCID 19913021, compound

Procedure

A mixture of 0.61 g of 1,3-dimethyl-4-methylthio-5-nitro-1,2,3,6-tetrahydropyridylmethylamine, 0.357 g of 3 pyridylmethylamine and 6 ml of acetonitrile was stirred at room temperature for 5 hours. The reaction mixture was then concentrated and purified by column chromatography (eluent: dichloromethane-methanol (10:1)) to give 0.33 g of 1,3-dimethyl-4-(pyridylmethylamino)-5 nitro-1,2,3,6-tetrahydropyrimidine (Compound No. 31) as a syrup.

Workup

  1. concentrationThe reaction mixture was then concentrated
  2. custompurified by column chromatography (eluent: dichloromethane-methanol (10:1))

Sources & evidence

ORD record
ord-9407ead0656b41e49570000e563788a1
Source dataset
uspto-grants-1992_01
Patent number
US05084459

Reaction notes

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