反应详情

温度

20 °C

Methylamine (g) was bubbled through a stirring solution of 2-(chloromethyl)-6-nitroquinoline (5.00 g, 22.47 mmol) in toluene (70 mL) at 0° C. The mixture was slowly warmed to 20° C. over 4 hours, concentrated to 1/2 volume, and partitioned between 10% aqueous K2CO3 /ethyl acetate. The organic phase was dried (MgSO4), decolorized (charcoal) and concentrated. Yield: 4.89 g as a brown solid which was used without purification.

1. concentrationconcentrated to 1/2 volume
2. custompartitioned between 10% aqueous K2CO3 /ethyl acetate
3. dry with materialThe organic phase was dried (MgSO4)
4. concentrationconcentrated
5. customYield: 4.89 g as a brown solid which was used without purification