Toluene → Methyl 3-amino-3-methylbutanoate

HRID 1091234노트

반응식

HRID 1091234 반응식
[NH2:1][C:2]([CH3:8])([CH3:7])[CH2:3][C:4]([OH:6])=[O:5].S(Cl)(Cl)=O.[C:13]1(C)C=CC=CC=1>CO>[NH2:1][C:2]([CH3:8])([CH3:7])[CH2:3][C:4]([O:6][CH3:13])=[O:5]

참가 물질

5

반응물 3

HCID 1140TolueneHCID 24386Thionyl ChlorideHCID 27609333-Amino-3-methylbutanoic acid

생성물 1

HCID 18667677Methyl 3-amino-3-methylbutanoate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To 3-amino-3-methyl-butyric acid 10-1 (1 eq.) in methanol at 0° C. was added 2 eq. of thionyl chloride. The reaction mixture was warmed to room temperature and stirred overnight. The solvent was evaporated to give azeotropic mixture of 10-2 and toluene (x=3) which was used for Step B. MS: MH+=132.1

후처리

  1. customThe solvent was evaporated
  2. customto give azeotropic

출처 및 근거

ORD 기록
ord-12eab62409644f549ff42be168d97b7a
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08129358B2

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