HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → Methyl 3-amino-3-methylbutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-Amino-3-methylbutanoic acid | HCID 2760933 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 3-amino-3-methylbutanoate | HCID 18667677 | — |
Reaction Steps
To 3-amino-3-methyl-butyric acid 10-1 (1 eq.) in methanol at 0° C. was added 2 eq. of thionyl chloride. The reaction mixture was warmed to room temperature and stirred overnight. The solvent was evaporated to give azeotropic mixture of 10-2 and toluene (x=3) which was used for Step B. MS: MH+=132.1
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08129358B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-12eab62409644f549ff42be168d97b7a |
| Source note | uspto-grants-2012_03 |