Acetic Acid → HCID 66592470, compound

HRID 1091289Notes

Reaction equation

HRID 1091289 reaction equation
C([N:14]1[CH2:17][CH:16]([CH2:18][OH:19])[CH2:15]1)(C1C=CC=CC=1)C1C=CC=CC=1.[C:20](O)(=[O:22])[CH3:21]>C(O)C.[OH-].[OH-].[Pd+2]>[C:20]([O:19][CH2:18][CH:16]1[CH2:15][NH:14][CH2:17]1)(=[O:22])[CH3:21]

Participants

5

Reactant 2

HCID 176Acetic AcidHCID 2758715(1-Benzhydrylazetidin-3-yl)methanol

Product 1

HCID 66592470HCID 66592470, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

(1-Benzhydrylazetidin-3-yl)methanol (1.81 g, 7.16 mmol) was dissolved in ethanol (50 mL), and acetic acid (0.82 mL, 14.32 mmol) and 10% palladium hydroxide/carbon (1.2 g) were added at room temperature. The mixture was stirred for three days under a hydrogen stream at normal pressure. The catalyst was separated by filtration, and the reaction liquor was concentrated under reduced pressure, to obtain the title compound as an oily matter. This compound was used in the subsequent reaction without being subjected to further purification.

Workup

  1. customThe catalyst was separated by filtration
  2. concentrationthe reaction liquor was concentrated under reduced pressure

Sources & evidence

ORD record
ord-7eddb491bf464bec9e4d8e22462689ae
Source dataset
uspto-grants-2012_03
Patent number
US08129366B2

Reaction notes

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