Acetic Acid → HCID 66591971, compound

HRID 1091302Notes

Reaction equation

HRID 1091302 reaction equation
C([N:8]1[CH2:13][CH:12]([CH3:14])[O:11][CH:10]([CH3:15])[CH2:9]1)C1C=CC=CC=1.[C:16]([OH:19])(=[O:18])[CH3:17]>C(O)C.[OH-].[OH-].[Pd+2]>[C:16]([OH:19])(=[O:18])[CH3:17].[CH3:15][CH:10]1[O:11][CH:12]([CH3:14])[CH2:13][NH:8][CH2:9]1

Participants

5

Reactant 2

HCID 176Acetic AcidHCID 122940934-Benzyl-2,6-dimethylmorpholine

Product 1

HCID 66591971HCID 66591971, compoundYield 92%

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

4-Benzyl-2,6-dimethylmorpholine (10.72 mg, 45.76 mmol) was dissolved in acetic acid (10 mL) and ethanol (200 mL), and 10% palladium hydroxide/carbon (5 g) was added thereto. The mixture was stirred for two days at room temperature under a hydrogen stream at normal pressure. The catalyst was separated by filtration, and then the reaction liquor was concentrated under reduced pressure and dried, to obtain the title compound (7.36 g, 92%) as an oily matter. This compound was used in the subsequent reaction without performing further purification.

Workup

  1. customThe catalyst was separated by filtration
  2. concentrationthe reaction liquor was concentrated under reduced pressure
  3. customdried

Sources & evidence

ORD record
ord-69a9203784cf4e1faba18f42c935af9c
Source dataset
uspto-grants-2012_03
Patent number
US08129366B2

Reaction notes

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