1,4-Dioxane hydrochloride → HCID 20818712, compound

HRID 1091303Notes

Reaction equation

HRID 1091303 reaction equation
C(OC([N:8]1[C@H:13]([CH3:14])[CH2:12][O:11][CH2:10][C@@H:9]1[CH3:15])=O)(C)(C)C.[ClH:16].O1CCOCC1>>[ClH:16].[CH3:15][C@H:9]1[CH2:10][O:11][CH2:12][C@@H:13]([CH3:14])[NH:8]1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 20818713HCID 20818713, compound

Product 1

HCID 20818712HCID 20818712, compound

Procedure

Cis-4-tert-butoxycarbonyl-3,5-dimethylmorpholine g, 8.18 mmol) was dissolved in 4N-hydrochloric acid/1,4-dioxane (50 mL), and the solution was stirred for 3 days at room temperature. The reaction liquor was concentrated under reduced pressure and dried, to obtain the title compound as an oily matter. This compound was used in the subsequent reaction without performing further purification.

Workup

  1. concentrationThe reaction liquor was concentrated under reduced pressure
  2. customdried

Sources & evidence

ORD record
ord-cc9905dbfa404b7187cd27cc1a476058
Source dataset
uspto-grants-2012_03
Patent number
US08129366B2

Reaction notes

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